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CAS RN: 54856-23-4 | Product Number: B1424
Betahistine Methanesulfonate
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Purity: >99.0%(T)(HPLC)
Synonyms:
- Betahistine Mesylate
- 2-[2-(Methylamino)ethyl]pyridine Methanesulfonate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€69.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B1424 |
| Purity / Analysis Method | >99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__2N__2·2CH__4O__3S = 328.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 54856-23-4 |
| Related CAS RN | 5638-76-6 |
| Reaxys Registry Number | 4043104 |
| PubChem Substance ID | 87564344 |
| MDL Number | MFCD00143688 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Purity(Neutralization titration) | min. 99.0 % |
| Melting point | 112.0 to 115.0 °C |
| Solubility in Water | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 112 °C |
GHS
Related Laws:
| EC Number | 259-377-7 |
| RTECS# | UT2970200 |
Transport Information:
| HS Number | 2933399990 |
Application
Betahistine Methanesulfonate: A Histamine H1 Receptor Agonist/H3 Antagonist
Betahistine methanesulfonate is a structural analog of histamine [H0146, dihydrochloride] that acts both as a partial histamine H1-receptor agonist and histamine H3-receptor antagonist in neuronal tissue. Betahistine increases histamine turnover and release by blocking presynaptic H3-receptors and inducing H3-receptor downregulation.1-3) Reportedly, betahistine increases in vestibular blood flow, and is used as an antivertigo agent in clinical.2,3) Recently, it has been reported that betahistine induced the recall of forgotten memories in mice.4) (The product is for research purpose only.)
References
- 1) Actions of betahistine at histamine receptors in the brain
- 2) Betahistine increases vestibular blood flow
- 3) Histamine and betahistine in the treatment of vertigo: Elucidation of mechanisms of action (a review)
- 4) Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories
- 5) LC-MS-MS analysis of 2-pyridylacetic acid, a major metabolite of betahistine: application to a pharmacokinetic study in healthy volunteers
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