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Published TCIMAIL newest issue No.197
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CAS RN: 89-57-6 | Product Number: A0317
5-Aminosalicylic Acid
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Purity: >98.0%(T)
Synonyms:
- 5-Amino-2-hydroxybenzoic Acid
- Mesalamine
- Mesalazine
- 5-ASA
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
23,00 €
|
3 | ≥100 |
|
| 500G |
178,00 €
|
1 | 21 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A0317 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__7H__7NO__3 = 153.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive |
| CAS RN | 89-57-6 |
| Reaxys Registry Number | 2090421 |
| PubChem Substance ID | 87561970 |
| SDBS (AIST Spectral DB) | 3423 |
| Merck Index (14) | 5904 |
| MDL Number | MFCD00007877 |
Specifications
| Appearance | White to Gray to Brown powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Solubility in HCl | almost transparency |
Properties (reference)
| Melting Point | 265 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 201-919-1 |
| RTECS# | VO1400000 |
Transport Information:
| HS Number | 2922500090 |
Application
5-Aminosalicylic Acid (5-ASA): A Gastrointestinal Anti-Inflammatory Agent
5-Aminosalicylic acid (5-ASA or mesalazine) is used as a gastrointestinal anti-inflammatory agent. Although the mechanism of action remains unknown exactly, 5-ASA has in vitro and in vivo pharmacologic effects that decrease leukotriene production, scavenge for free radicals and inhibit leukocyte chemotaxis et al. For clinical purposes, amylose, ethyl cellulose or pH-dependent polymers coated 5-ASA are developed and used for drug delivery to the intestinal tract. In addition, sulfasalazine [S0580] is a prodrug of 5-ASA. (The product is for research purpose only.)
References
- Salicylates for ulcerative colitis - their mode of action (a review)
- Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers
- 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells
- Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-γ
- Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid
- High-performance liquid-chromatographic determination of 5-aminosalicylic acid and its metabolites in blood plasma
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5-Aminosalicylic Acid [for Biochemical Research]
| Product # | A2291 |
| CAS RN | 89-57-6 |
| Purity / Analysis Method: | >98.0%(T) |