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CAS RN: 14222-60-7 | Product Number: P2302
Prothionamide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Propylpyridine-4-carbothioamide
- 2-Propylthioisonicotinamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 5G |
$48.00
|
≥40 | Contact Us |
| 25G |
$152.00
|
20 | Contact Us |
* Please contact our distributors or
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | P2302 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2S = 180.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 14222-60-7 |
| Reaxys Registry Number | 118164 |
| PubChem Substance ID | 253660961 |
| Merck Index (14) | 7891 |
| MDL Number | MFCD00464119 |
Specifications
| Appearance | Light yellow to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 141.0 to 145.0 °C |
Properties (reference)
| Melting Point | 143 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NS0650000 |
Transport Information:
| H.S.code* | 2933.39-000 |
Application
Prothionamide: A Thioamide Anti-Tuberculosis Agent
Prothionamide and ethionamide [E0695] are thioamide anti-tuberculosis agents. They have activity against Mycobacterium tuberculosis, Mycobacterium leprae murium and Mycobacterium avium. The precise mechanisms of action remain unknown, but it has been reported that the thioamides are prodrugs that are oxidatively converted to their active forms by the flavin monooxygenase EtaA of Mycobacterium tuberculosis.
References
- Mechanism of thioamide drug action against tuberculosis and leprosy
- Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases (a review)
- High-performance liquid chromatographic determination of ethionamide and prothionamide in body fluids
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