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CAS RN: 635702-64-6 | Product Number: P2243
Pazopanib Hydrochloride
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Purity: >95.0%(T)(HPLC)
Synonyms:
- 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 50MG |
$77.00
|
≥40 | Contact Us |
| 250MG |
$247.00
|
Contact Us | 12 |
* Please contact our distributors or
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | P2243 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__3N__7O__2S·HCl = 473.98 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 635702-64-6 |
| PubChem Substance ID | 468592583 |
| MDL Number | MFCD12546138 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Water | max. 3.0 % |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Pazopanib Hydrochloride: An Oral Small Molecule Multi-Tyrosine Kinase Inhibitor
Pazopanib hydrochloride (GW786034B) is an oral small molecule multi-tyrosine kinase inhibitor. It has been demonstrated that pazopanib shows inhibitory action for vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, VEGFR-3, platelet-derived growth factor receptor (PDGFR)-α and β, fibroblast growth factor receptor (FGFR)-1 and -3, cytokine receptor (Kit), interleukin-2 receptor-inducible T-cell kinase (Itk), lymphocyte-specific protein-tyrosine kinase (Lck), and transmembrane glycoprotein receptor tyrosine kinase (c- Fms). Pazopanib is thought to inhibit tumor growth by inhibiting the activation of VEGFR and PDGFR related to angiogenesis, which is involved in tumor growth. (The product is for research purpose only.)
References
- The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma
- Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor
- Pazopanib: a novel multitargeted tyrosine kinase inhibitor (a review)
- Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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