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CAS RN: 459789-99-2 | Product Number: O0641
Obeticholic Acid
×
Purity: >97.0%(GC)(T)
Synonyms:
- 6-ECDCA
- 6-Ethylchenodeoxycholic Acid
- 6-Ethyl-3α,7α-dihydroxycholan-24-oic Acid
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$159.00
|
16 | 0 | It can be shipped in about 2 weeks after ordering |
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* The storage conditions are subject to change without notice.
| Product Number | O0641 |
Purity / Analysis Method 
|
>97.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__2__6H__4__4O__4 = 420.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 459789-99-2 |
| Reaxys Registry Number | 9238543 |
| MDL Number | MFCD16621104 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation | +3.3 to +5.5 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 109 °C |
GHS
Related Laws:
| RTECS# | FZ2267000 |
Transport Information:
| H.S.code* | 2918.19-000 |
Application
Obeticholic Acid: A Potent and Selective Agonist of Farnesoid X Receptor (FXR)
Farnesoid X receptor (FXR), a nuclear receptor, is a ligand-activated transcription factor involved in the control of bile acid (BA) synthesis and enterohepatic circulation, and a regulator of glucose and lipid metabolism. Obeticholic acid (6-ECDCA, INT-747) is a semi-synthetic mimetic of the primary human bile acid, chenodeoxycholic acid (CDCA) [C0750]. There are reports that obeticholic acid is a potent and selective activator of FXR that reduces hepatic steatosis and fibrosis in animal models of fatty liver disease. (The product is for research purpose only.)
References
- 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity
- Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action (a review)
- The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer (a review)
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