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CAS RN: 912-60-7 | Product Number: N0963
Noscapine Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
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| Product Number | N0963 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__3NO__7·HCl = 449.88 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 912-60-7 |
| Related CAS RN | 128-62-1&219533-73-0 |
| PubChem Substance ID | 253660822 |
| MDL Number | MFCD00149223 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | +43.0 to +47.0 deg(C=0.5, 0.1mol/L HCl)(calcd.on dried.substance) |
| Drying loss | max. 9.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 200 °C(dec.) |
| Specific Rotation | 45° (C=0.5,0.1 mol/L HCl) |
| Solubility (soluble in) | Ethanol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | NP7225000 |
Transport Information:
| H.S.code* | 2939.19-000 |
Application
抗腫瘍性イソキノリンアルカロイド，ノスカピン塩酸塩
Noscapine hydrochloride is an isoquinoline alkaloid found in opium latex, not having anesthetic and analgesic properties. Noscapine is being used as an antitussive agent for a long time has been recently discovered as a novel tubulin-binding, anti-angiogenic anticancer agent that causes cell cycle arrest and induces apoptosis in cancer cells. (The product is for research purpose only.)
References
- Noscapine (a review)
- Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells
- Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation
- The anti-cancer activity of noscapine: a review
- A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine
- A review on noscapine, and its impact on heme metabolism
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