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CAS RN: 50-07-7 | Product Number: M2320
Ametycin
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Purity: >98.0%(HPLC)
Synonyms:
- Mitomycin C
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 10MG |
$108.00
|
36 | ≥60 |
| 50MG |
$368.00
|
9 | 32 |
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* The storage conditions are subject to change without notice.
| Product Number | M2320 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__8N__4O__5 = 334.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 50-07-7 |
| Reaxys Registry Number | 3570056 |
| PubChem Substance ID | 172088986 |
| Merck Index (14) | 6215 |
| MDL Number | MFCD00078109 |
Specifications
| Appearance | Dark red to Dark purple to Dark blue powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 16.4 to 17.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 64 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H361 : Suspected of damaging fertility or the unborn child. H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | CN0700000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| H.S.code* | 2941.90-000 |
Application
Ametycin: A DNA Interstrand Cross-Linking Agent
Ametycin (also known as Mitomycin C) is an antitumor antibiotic and a bifunctional alkylating agent, first isolated from the broth filtrate of Streptomyces caespitosus by Hata et al. (Kitasato Institute) in 1955. Some metabolic activation forms of ametycin inhibit DNA synthesis by causing cross-linking specificity for the sequence CpG. Ametycin causes cell cycle arrest in phase-nonspecific but is most active in S and G phases, and induces apoptosis in cancer cells.
References
- Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
- DT-diaphorase in activation and detoxification of quinones: bioreductive activation of mitomycin C (a review)
- Mitomycin C: small, fast and deadly (but very selective) (a review)
- The mitomycin bioreductive antitumor agents: crosslinking and alkylation of DNA as the molecular basis of their activity (a review)
- Formation and Repair of Interstrand Cross-Links in DNA (a review)
PubMed Literature
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