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CAS RN: 101152-94-7 | Product Number: M2133
Milnacipran Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- cis-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
$33.00
|
6 | 15 | It can be shipped in about 2 weeks after ordering | |
| 500MG |
$189.00
|
6 | 9 | It can be shipped in about 2 weeks after ordering |
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| Product Number | M2133 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__2N__2O·HCl = 282.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 101152-94-7 |
| Related CAS RN
|
92623-85-3 |
| Reaxys Registry Number | 6078861 |
| PubChem Substance ID | 125307702 |
| Merck Index (14) | 6194 |
| MDL Number | MFCD00901293 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 181 °C(dec.) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | GZ1014010 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2924.29-000 |
Application
Milnacipran hydrochloride: A Selective Serotonin Noradrenaline Reuptake Inhibitor (SNRI)
Milnacipran hydrochloride is a selective serotonin noradrenaline reuptake inhibitor (SNRI) which acts by inhibiting noradrenaline (norepinephrine) and serotonin (5-hydroxytrytamine; 5-HT) reuptake at presynaptic sites. Milnacipran has unique characteristics that distinguish it from the other SNRIs, venlafaxine [V0110] and duloxetine [D4223], such as inhibition of noradrenaline reuptake with approximately 3-fold higher potency in vitro than serotonin. Milnacipran has no significantt affinity for other neurotransmitter receptors, such as serotonergic, α- and β-adrenergic, muscarinic, histamine, dopamine, opioid, benzodiazepine, and γ-aminobutyric acid (GABA) receptors in vitro. Milnacipran does not inhibit the activity of human monoamine oxidases (MAO-A and MAO-B) or acetylcholinesterase. (The product is for research purpose only.)
References
- Selective serotonin/noradrenaline reuptake inhibitors (SNRIs). Pharmacology and therapeutic potential in the treatment of depressive disorders (a review)
- Neurochemical and behavioral characterization of Milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats
- Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity
- High-performance liquid chromatographic method to screen and quantitate seven selective serotonin reuptake inhibitors in human serum
- A stability indicating U-HPLC method for milnacipran in bulk drugs and pharmaceutical dosage forms
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