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CAS RN: 191732-72-6 | Product Number: L0332
Lenalidomide
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Purity: >98.0%(HPLC)
Synonyms:
- 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
- 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 250MG |
$109.00
|
5 | 1 |
| 1G |
$305.00
|
Contact Us | 10 |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | L0332 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__3N__3O__3 = 259.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 191732-72-6 |
| MDL Number | MFCD07772307 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
Properties (reference)
| Melting Point | 271 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.3 g/l |
| Solubility (insoluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | TW7342160 |
Transport Information:
| H.S.code* | 2933.79-000 |
Application
Lenalidomide: An Immunomodulatory Agent with Antiangiogenic and Antineoplastic Properties
Lenalidomide (CC-5013), a more potent thalidomide [T2524] analogue such as pomalidomide [P2074], is an immunomodulatory agent with antiangiogenic and antineoplastic properties. It is reported that lenalidomide inhibits proliferation and induces apoptosis of certain hematopoietic tumor cells including multiple myeloma, mantle cell lymphoma, and myelodysplastic syndromes in vitro. Immunomodulatory properties of lenalidomide include activation of T cells and natural killer (NK) cells, increased numbers of NKT cells, and inhibition of pro-inflammatory cytokines (e.g., TNF-α and IL-6) by monocytes. (The product is for research purpose only.)
References
- Dexamethasone Synergizes with Lenalidomide to Inhibit Multiple Myeloma Tumor Growth, But Reduces Lenalidomide-Induced Immunomodulation of T and NK Cell Function
- Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma (a review)
- Development and validation of LC-MS/MS method for the quantitation of lenalidomide in human plasma using Box-Behnken experimental design
- Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: Application to a pharmacokinetic study
Articles/Brochures
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