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Published TCIMAIL newest issue No.197 | Notice of Discontinuing the Use of Password-Protected Compressed Files | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
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CAS RN: 183133-96-2 | Product Number: C3390
Cabazitaxel
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Purity: >98.0%(HPLC)
Synonyms:
- XRP 6258
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$104.00
|
3 | 0 | It can be shipped in about 2 weeks after ordering | |
| 100MG |
$308.00
|
2 | 0 | It can be shipped in about 2 weeks after ordering |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | C3390 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__5H__5__7NO__1__4 = 835.94 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 183133-96-2 |
| Reaxys Registry Number | 14351224 |
| PubChem Substance ID | 468591103 |
| MDL Number | MFCD18827611 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 180 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Cabazitaxel: A Microtubule Inhibitor for Docetaxel-Resistant Tumors
Cabazitaxel (TXD258), a semi-synthetic taxane antitumor agent, is prepared from 10-deacetylbaccatin III [D4148]. Cabazitaxel is a microtubule inhibitor. Cabazitaxel binds to tubulin and promotes the tubulin polymerization. This leads to the stabilization of microtubules, which results in the inhibition of mitotic and interphase cellular functions. Different from docetaxel [D4102], cabazitaxel is a poor substrate for the P-glycoprotein (P-gp) which pumps many foreign substances out of cells. Therefore, cabazitaxel is expected to have antitumor activity in docetaxel resistant cancers. In addition, cabazitaxel can cross the blood-brain barrier. (The product is for research purpose only.)
References
- Nonlinear accumulation in the brain of the new taxoid TXD258 following saturation of P-glycoprotein at the blood-brain barrier in mice and rats
- Cabazitaxel (a review)
- Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer (a review)
- Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
- Development of a rapid and sensitive UPLC-MS/MS assay for the determination of TM-2 in beagle dog plasma and its application to a pharmacokinetic study
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