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CAS RN: 501-53-1 | Product Number: B3021
Benzyl Chloroformate
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Purity: >96.0%(T)
Synonyms:
- Chloroformic Acid Benzyl Ester
- Carbobenzoxy Chloride
- Cbz Chloride
- Cbz-Cl
- Z-Cl
- Benzyloxycarbonyl Chloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 25G |
$28.00
|
≥80 | Contact Us |
| 250G |
$66.00
|
28 | Contact Us |
* Please contact our distributors or
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | B3021 |
| Purity / Analysis Method | >96.0%(T) |
| Molecular Formula / Molecular Weight | C__8H__7ClO__2 = 170.59 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive,Heat Sensitive |
| CAS RN | 501-53-1 |
| Reaxys Registry Number | 509751 |
| PubChem Substance ID | 87560103 |
| SDBS (AIST Spectral DB) | 50783 |
| Merck Index (14) | 1801 |
| MDL Number | MFCD00000640 |
Specifications
| Appearance | Colorless to Light yellow clear liquid |
| Purity(GC) | min. 94.0 % |
| Purity(Argentometric Titration) | min. 96.0 % |
Properties (reference)
| Melting Point | 0 °C |
| Boiling Point | 103 °C/20 mmHg |
| Flash point | 80 °C |
| Specific Gravity (20/20) | 1.21 |
| Refractive Index | 1.52 |
| Solubility (soluble in) | Benzene, Ether, Acetone, Chloroform, Toluene |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H330 : Fatal if inhaled. H314 : Causes severe skin burns and eye damage. H410 : Very toxic to aquatic life with long lasting effects. H227 : Combustible liquid. H290 : May be corrosive to metals. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P210 : Keep away from heat/sparks/open flames/hot surfaces. No smoking. P234 : Keep only in original container. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P390 : Absorb spillage to prevent material damage. P391 : Collect spillage. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 : Wash contaminated clothing before reuse. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P403 + P235 : Store in a well-ventilated place. Keep cool. P406 : Store in corrosive resistant container with a resistant inner liner. P405 : Store locked up. |
Related Laws:
| RTECS# | LQ5860000 |
Transport Information:
| UN Number | UN1739 |
| Class | 8 |
| Packing Group | I |
| H.S.code* | 2916.39-000 |
Application
TCI Practical Example: Cbz-Protection Reaction of an Amino Group
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Used Chemicals
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Procedure
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Benzyl carbonochloridate (1.69 mL, 12 mmol) was added dropwise with a syringe to a solution of triethylamine (2.8 mL, 20 mmol) and benzylamine (1.1 mL, 10 mmol) in dichloromethane (20 mL), cooling with ice/water and stirred at room temperature for 24 hours. The reaction mixture was washed with water (20 mL) and the aqueous layer was extracted with dichloromethane (10 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (hexane:ethyl acetate=3:1) to afford N-(benzyloxycarbonyl)benzylamine (1.98 g, 82% yield) as a white solid.
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Experimenter’s Comments
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The reaction solution was monitored by UPLC.
The solvent was dehydrated with MS4A before use.
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Analytical Data
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N-(Benzyloxycarbonyl)benzylamine
1H NMR (400 MHz, DMSO-d6); δ 7.37-7.28 (m, 10H), 5.13 (s, 2H), 5.09 (s, 1H), 4.40 (d, J = 6.0 Hz, 2H).
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Other References
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- Diborylmethyl Group as a Transformable Building Block for the Diversification of Nitrogen-Containing Molecules
Application
Selective Protection of Aromatic Amines
Reference
PubMed Literature
Articles/Brochures
TCIMAIL
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Safety Data Sheet (SDS)
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Specifications
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Other Documents
Related Products
Benzyl Chloroformate (30-35% in Toluene)
| Product # | C0176 |
| CAS RN | 501-53-1 |
| Purity / Analysis Method: |