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CAS RN: 497839-62-0 | Product Number: A3271
AEE 788
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Purity: >98.0%(HPLC)
Synonyms:
- (R)-6-[4-[(4-Ethylpiperazin-1-yl)methyl]phenyl]-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days |
|---|---|---|---|
| 5MG |
$133.00
|
11 | Contact Us |
| 25MG |
$468.00
|
14 | 10 |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | A3271 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__3__2N__6 = 440.60 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 497839-62-0 |
| Reaxys Registry Number | 11326138 |
| PubChem Substance ID | 468590207 |
| MDL Number | MFCD11100351 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 245.0 to 249.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 247 °C |
GHS
Related Laws:
| RTECS# | UY8836200 |
Transport Information:
| H.S.code* | 2933.59-000 |
Application
AEE788: A Dual Inhibitor of EGFR and VEGFR Tyrosine Kinase Family Members
AEE788 is an orally available and potent dual family of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) tyrosine kinases inhibitor. It has been reported that AEE788 exhibits potent antitumor and antiangiogenic activity. (The product is for research purpose only.)
References
- AEE788: A Dual Family Epidermal Growth Factor Receptor/ErbB2 and Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor with Antitumor and Antiangiogenic Activity
- Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model
- Combined inhibition of the VEGFR and EGFR signaling pathways in the treatment of NSCLC (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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