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CAS RN: 138982-67-9 | Product Number: Z0032
Ziprasidone Hydrochloride Monohydrate
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Purity: >98.0%(HPLC)
Synonyms:
- 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one Hydrochloride Monohydrate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$51.00
|
1 | 1 | 12 |
|
| 250MG |
$163.00
|
1 | 1 | 9 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | Z0032 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__1ClN__4OS·HCl·H__2O = 467.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 138982-67-9 |
| Related CAS RN | 122883-93-6&146939-27-7 |
| Reaxys Registry Number | 13262593 |
| PubChem Substance ID | 253661772 |
| Merck Index (14) | 10171 |
| MDL Number | MFCD00921885 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Water | 3.7 to 5.0 % |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
| RTECS# | NM3241200 |
Transport Information:
| HS Number | 2934.20.8000 |
Application
Ziprasidone: A Selective Antagonist at the Dopamine D2, Serotonin 5HT2A, and 5HT1D Receptors
Ziprasidone hydrochloride monohydrate is a benzisothiazolyl piperazine-type atypical antipsychotic that shares the serotonin2A/dopamine2 (5-HT2A/D2) profile of the atypical antipsychotics. Ziprasidone functioned as a selective antagonist at the D2, 5HT2A, and 5HT1D receptors, and also as an agonist at the 5HT1A receptor. Ziprasidone is hepatically metabolized by aldehyde oxidase and cytochrome P450 3A4 (CYP3A4). (The product is for research purpose only.)
References
- Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity
- 5-HT1A receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex
- Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile
- Ziprasidone Metabolism, Aldehyde Oxidase, and Clinical Implications (a review)
- Development and validation of a rapid RP-HPLC method for the estimation of Ziprasidone Hydrochloride Monohydrate in bulk and its capsule dosage forms
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