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CAS RN: 20235-78-3 | Product Number: T4108
2-Thiouridine
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- 1-β-D-Ribofuranosyl-2-thiouracil
- 1-β-D-Ribofuranosyl-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone
- 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$150.00
|
Contact Us | 1 | 36 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T4108 |
| Purity / Analysis Method | >98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2O__5S = 260.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 20235-78-3 |
| Reaxys Registry Number | 28752 |
| MDL Number | MFCD03788697 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 215 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934.99.9001 |
Application
2-Thiouridine: A Sulfur-Containing Thioribonucleoside Found in tRNA
2-Thiouridine (s2U) is a sulfur-containing thioribonucleoside found in tRNA. Thioribonucleosides have been reported to perform essential functions for accurate and efficient translation, including proper codon recognition in mRNA or stabilization of tRNA structure. In addition, 2-thiouridine is stabilizes U:A pairs and destabilizes U:G wobble pairs. Thus, thioribonucleosides, including 2-thiouridine, are used to study nucleic acid structure and function.
References
- Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex
- Biosynthesis and functions of sulfur modifications in tRNA (a review)
- Transfer RNA modification: presence, synthesis, and function (a review)
- Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension
- Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization
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