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CAS RN: 13957-31-8 | Product Number: T4059
4-Thiouridine
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Purity: >95.0%(qNMR)
Synonyms:
- 1-β-D-Ribofuranosyl-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
- 1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
$84.00
|
Contact Us | Contact Us | 1 |
|
| 100MG |
$210.00
|
Contact Us | Contact Us | 4 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | T4059 |
| Purity / Analysis Method | >95.0%(qNMR) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2O__5S = 260.26 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 13957-31-8 |
| Reaxys Registry Number | 28750 |
| MDL Number | MFCD00006538 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 140 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934.99.9001 |
Application
4-Thiouridine: A Photoactive Ribonucleoside Analog Used for RNA Analysis Methods
4-Thiouridine (s4U or 4sU) is a photoactive ribonucleoside analog found in transfer RNA (tRNA), and absorbs light at wavelengths longer than 320 nm and, thus, can be selectively photo-activated.1,2) Recently, 4-thiouridine has been widely used for RNA analysis methods based on the photo-activity, such as PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation)3-5) and SLAM seq (thiol (SH)-linked alkylation for the metabolic sequencing of RNA)6). (The product is for research purpose only.)
References
- 1) Thionucleobases as intrinsic photoaffinity probes of nucleic acid structure and nucleic acid-protein interactions (a review)
- 2) Site-specific RNA crosslinking with 4-thiouridine (a review)
- 3) Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP
- 4) PAR-CLIP (photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation): a step-by-step protocol to the transcriptome-wide identification of binding sites of RNA-binding proteins (a review)
- 5) Optimization of PAR-CLIP for transcriptome-wide identification of binding sites of RNA-binding proteins (a review)
- 6) Thiol-linked alkylation of RNA to assess expression dynamics
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