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CAS RN: 32986-56-4 | Product Number: T2503
Tobramycin
×
Purity: >94.0%(T)
Synonyms:
- O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 5G |
$124.00
|
5 | 1 | ≥40 |
|
|
| 25G |
$495.00
|
3 | 2 | 8 |
|
* Items in stock locally typically ship the same day of ordering. Items from Japan stock are able to ship from a US warehouse within 2 weeks after ordering. For additional estimated shipment times, please refer to the Shipping Simulation tool. Note: Excludes regulated items and items that ship on ice.
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| Product Number | T2503 |
Purity / Analysis Method 
|
>94.0%(T) |
| Molecular Formula / Molecular Weight | C__1__8H__3__7N__5O__9 = 467.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 32986-56-4 |
| Reaxys Registry Number | 1357507 |
| PubChem Substance ID | 87560061 |
| Merck Index (14) | 9490 |
| MDL Number | MFCD00077885 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(Nonaqueous Titration) | min. 94.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | +138.0 to +148.0 deg(C=4, H2O)(calcd.on anh.substance) |
| Water | max. 8.0 % |
Properties (reference)
| Melting Point | 178 °C |
| Specific Rotation | 143° (C=4,H2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
| RTECS# | WK2100000 |
Transport Information:
| HS Number | 2941.10.5000 |
Application
Biofilm research
Effect of tobramycin on biofilm cells in Pseudomonas aeruginosa has been reported.1,2) The bacterial cells in biofilm formed on catheter material exhibited highly resistance to the antimicrobial agent and planktonic cells were killed by the agent.1) Study using in vitro chemostat system showed also that cells in old biofilm were more resistant to tobramycin in comparison with cells in young biofilm.2)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Tobramycin Resistance of Pseudomonas aeruginosa Cells Growing as a Biofilm on Urinary Catheter Material
- 2) Interaction of Biofilm Bacteria with Antibiotics in a Novel In Vitro Chemostat System
- Direct Selection of RNA Beacon Aptamers
- Specific binding of aminoglycoside antibiotics to RNA
- Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use
- The aminoglycosides: streptomycin, kanamycin, gentamicin, tobramycin, amikacin, netilmicin, and sisomicin (a review)
- Tobramycin Inhalation Powder: a novel drug delivery system for treating chronic Pseudomonas aeruginosa infection in cystic fibrosis
- Tobramycin Inhalation Powder: A Review of Its Use in the Treatment of Chronic Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis
Application
RNA aptamer research
References
Application
Tobramycin: An Aminoglycoside Antibiotic Active Against Pseudomonas Aeruginosa
Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius, and is similar in structure to gentamicin [G0383]. Tobramycin interacts with the 30s and 50s subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Tobramycin is more active than gentamicin against Pseudomonas aeruginosa and active against many gentamicin resistant strains. Recently, inhaled tobramycin is effective in treating chronic Pseudomonas aeruginosa lung infection in cystic fibrosis. (The product is for research purpose only.)
References
PubMed Literature
Documents
Product Articles
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Specifications
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