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CAS RN: 106266-06-2 | Product Number: R0087
Risperidone
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$16.00
|
3 | 1 | 22 |
|
| 500MG |
$82.00
|
3 | 1 | 28 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | R0087 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__7FN__4O__2 = 410.49 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 500MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 106266-06-2 |
| Reaxys Registry Number | 4891881 |
| PubChem Substance ID | 125307687 |
| Merck Index (14) | 8233 |
| MDL Number | MFCD00274576 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 170.0 to 174.0 °C |
Properties (reference)
| Melting Point | 172 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | UV1164800 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2934.99.4700 |
Application
Risperidone: A Dopamine D2 and Serotonin 5-HT2 Receptors Antagonist
Risperidone, a benzisoxazole derivative, acts as a dopamine type 2 (D2) and serotonin type 2 (5-HT2) receptors antagonist. In addition, risperidone has affinity for α1- and α2-adrenergic, and H1 histaminergic receptors. While, risperidone has low to moderate affinity for the serotonin 5-HT1C, 5-HT1D and 5-HT1A receptors, week affinity for the dopamine D1 and haloperidol-sensitive sigma binding site, and no affinity for cholinergic muscarinic or β1 and β2 adrenergic receptors. Its major active metabolite is paliperidone (9-hydroxyrisperidone) [P1897]. Risperidone is used as a long acting antipsychotic agent with relatively few side effects. (The product is for research purpose only.)
References
- Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties
- Biochemical profile of risperidone, a new antipsychotic
- Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding
- Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence
- Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
- The pharmacokinetics of paliperidone versus risperidone (a review)
- Simultaneous determination of clozapine, olanzapine, risperidone and quetiapine in plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry
Application
HDAC2 may be a New Target for Schizophrenia Treatment
Reference
- HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
PubMed Literature
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Safety Data Sheet (SDS)
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Specifications
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