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CAS RN: 110078-46-1 | Product Number: P2678
Plerixafor
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Purity: >98.0%(GC)
Synonyms:
- 1,4-Bis[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzene
- AMD 3100
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$99.00
|
1 | 1 | 5 |
|
| 250MG |
$297.00
|
Contact Us | Contact Us | 10 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | P2678 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__8H__5__4N__8 = 502.80 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| Packaging and Container | 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 110078-46-1 |
| Reaxys Registry Number | 4278367 |
| PubChem Substance ID | 468592671 |
| MDL Number | MFCD05662218 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 131.0 to 135.0 °C |
| Water | max. 13.0 % |
Properties (reference)
| Melting Point | 133 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2933.99.7500 |
Application
Plerixafor: A CXCR4 Chemokine Receptor Inhibitor and a Stem Cell Mobilization Agent
Plerixafor (AMD1300) was originally discovered as an anti-HIV agent effective in inhibiting the replication of HIV.1) However, at present, plerixafor has been used as a CXCR4 chemokine receptor inhibitor and a hematopoietic stem cell mobilization agent.2,3) Hematopoietic stem cells express CXCR4, a seven-transmembrane G-protein-coupled chemokine receptor. Plerixafor works as a CXCR4 chemokine receptor antagonist and blocks binding of its cognate ligand, stromal cell-derived factor-1α (SDF-1α). CXCR4 with its ligand SDF-1α has been reported to play an important role in engraftment of hematopoietic stem cells (HSCs) in the bone marrow. Plerixafor results in the rapid and reversible mobilization of hematopoietic stem cells into the peripheral circulation. (The product is for research purpose only.)
References
- 1) Synthesis and Structure-Activity Relationships of Phenylenebis(methylene)-Linked Bis-Tetraazamacrocycles That Inhibit HIV Replication. Effects of Macrocyclic Ring Size and Substituents on the Aromatic Linker
- 2) CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers (a review)
- 3) Physiology and Pharmacology of Plerixafor (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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