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CAS RN: 39562-70-4 | Product Number: N1186
Nitrendipine
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 3-Ethyl 5-Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Ethyl Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Ethyl Methyl Ester
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 250MG |
$62.00
|
Contact Us | Contact Us | Contact Us |
|
| 1G |
$186.00
|
Contact Us | Contact Us | 13 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | N1186 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__8H__2__0N__2O__6 = 360.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive |
| CAS RN | 39562-70-4 |
| Reaxys Registry Number | 498823 |
| PubChem Substance ID | 468592504 |
| Merck Index (14) | 6576 |
| MDL Number | MFCD00082255 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 157.0 to 161.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 159 °C |
| Maximum Absorption Wavelength | 352(MeOH) nm |
| Solubility (slightly sol. in) | Methanol, Ether |
GHS
Related Laws:
| RTECS# | US5653000 |
Transport Information:
| HS Number | 2933.39.6191 |
Application
Nitrendipine: A Vascular-Selective Dihydropyridine Calcium Channel Antagonist
Nitrendipine is a vascular-selective dihydropyridine calcium channel antagonist that causes vasodilatation by blocking the influx of calcium ions through L-type calcium channels in cell membranes. It is an effective antihypertensive agent and differs from other calcium channel antagonists in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. (The product is for research purpose only.)
References
- Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state
- Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension
- Simultaneous HPLC determination of nitrendipine and impurities of the process of synthesis
- Quantitative determination of nitrendipine and its metabolite dehydronitrendipine in human plasma using liquid chromatography-tandem mass spectrometry
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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