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CAS RN: 133407-82-6 | Product Number: M3244
MG-132
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Purity: >95.0%(qNMR)
Synonyms:
- Cbz-Leu-Leu-Leu-CHO
- Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal
- Benzyl [(S)-4-Methyl-1-[[(S)-4-methyl-1-[[(S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$100.00
|
Contact Us | Contact Us | 8 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | M3244 |
| Purity / Analysis Method | >95.0%(qNMR) |
| Molecular Formula / Molecular Weight | C__2__6H__4__1N__3O__5 = 475.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 133407-82-6 |
| Reaxys Registry Number | 7668447 |
| MDL Number | MFCD00674886 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(qNMR) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 84 °C |
GHS
Related Laws:
| RTECS# | OH2824610 |
Transport Information:
| HS Number | 2924.29.7790 |
Application
MG-132: A Tripeptide Aldehyde Proteasome Inhibitor
Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis. MG-132 (carbobenzyl-Leu-Leu-Leu-aldehyde) is the first developed tripeptide aldehyde proteasome inhibitor derived from a Chinese medicinal plant. Similarly to bortezomib [B5741], MG-132 inhibits the chymotrypsin-like proteolytic (β5) site of the 26S proteasome. MG-132 enhances cytostatic/cytotoxic effects of chemo- and radiotherapy, and increases apoptosis induced by other agents. (The product is for research purpose only.)
References
- MG132, a proteasome inhibitor, induces apoptosis in tumor cells (a review)
- Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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