Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 68767-14-6 | Product Number: L0244
Loxoprofen
×
![]()
×
Purity: >97.0%(T)(HPLC)
Synonyms:
- 2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic Acid
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$108.00
|
1 | 1 | ≥100 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | L0244 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__8O__3 = 246.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 68767-14-6 |
| Reaxys Registry Number | 2860055 |
| PubChem Substance ID | 354333699 |
| Merck Index (14) | 5589 |
| MDL Number | MFCD00864331 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 111 °C |
| Solubility (soluble in) | Methanol |
GHS
Related Laws:
Transport Information:
| HS Number | 2918.30.9000 |
Application
Loxoprofen: A Prodrug of Non-Steroidal Anti-Inflammatory Drug and a Non-Selective Cyclooxygenase Inhibitor
Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen[I0415], ketoprofen[K0038] and naproxen[M1021] among others. loxoprofen is a prodrug that is rapidly converted to its active trans-alcohol metabolite (loxoprofen-SRS) following oral administration. Loxoprofen is a non-selective cyclooxygenase inhibitor. It works by reducing the synthesis of prostaglandins from arachidonic acid. Loxoprofen has more potent analgesic activity than that of ketoprofen or naproxen. (The product is for research purpose only.)
References
- Species differences in metabolism of sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate (loxoprofen sodium), a new antiinflammatory agent
- Structural determination of rat urinary metabolites of sodium 2-[4-(2-oxocyclopentylmethyl)phenyl]propionate dihydrate (loxoprofen sodium), a new antiinflammatory agent
- Inhibition of prostaglandin production in the inflammatory tissue by loxoprofen-Na, an anti-inflammatory prodrug
- Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites
- Simultaneous analysis of several non-steroidal anti-inflammatory drugs in human urine by high-performance liquid chromatography with normal solid-phase extraction
- Rapid and simultaneous determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS with solid-phase extraction
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.