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CAS RN: 124750-99-8 | Product Number: L0232
Losartan Potassium
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Salt
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$179.00
|
9 | 7 | 3 |
|
| 25G |
$538.00
|
2 | 1 | ≥40 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | L0232 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__2ClKN__6O = 461.01 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 124750-99-8 |
| Reaxys Registry Number | 5900704 |
| PubChem Substance ID | 125307522 |
| SDBS (AIST Spectral DB) | 52825 |
| Merck Index (14) | 5583 |
| MDL Number | MFCD02092704 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
GHS
Related Laws:
| RTECS# | NI6755100 |
Transport Information:
| HS Number | 2933.99.9701 |
Application
Losartan Potassium: A Water-Soluble, Reversible and Non-Competitive Antagonist of the AT1 Receptor
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor, and an important component in the pathophysiology of hypertension. Angiotensin II can activate two different receptors, AT1 and AT2. The most important vasoconstrictor action of angiotensin II are mediate trough AT1 receptors. Losartan [L0378] is a prodrug, and its active metabolite (EXP3174) works as a reversible, non-competitive antagonist of the AT1 receptor.1,2) In addition, neither losartan nor its active metabolite inhibits ACE nor do they bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. In clinical, its water-soluble potassium salt (DUP 753) is used for the treatment of hypertension. Recently, AT1 receptor antagonists (blockers), such as losartan, are expected as therapeutics for reducing the aggressiveness and mortality from SARS-CoV-2 virus infections.3) (The product is for research purpose only.)
References
- 1) Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent
- 2) Losartan potassium: A review of its pharmacology, clinical efficacy and tolerability in the management of hypertension
- 3) Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
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Specifications
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