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CAS RN: 99011-02-6 | Product Number: I0747
Imiquimod
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
- 4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$67.00
|
2 | 1 | 18 |
|
| 1G |
$330.00
|
7 | 6 | ≥80 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | I0747 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__1__6N__4 = 240.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 99011-02-6 |
| Reaxys Registry Number | 7710060 |
| PubChem Substance ID | 87561300 |
| Merck Index (14) | 4922 |
| MDL Number | MFCD00866946 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 294 °C |
| Maximum Absorption Wavelength | 245(H2O/MeOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | NJ5903450 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2933.99.7900 |
Application
Imiquimod: A Toll-Like Receptor (TLR) 7 Agonist and a Potent Immune Activator
Imiquimod is reported as a Toll-like receptor (TLR) 7 agonist and a potent immune activator. Imiquimod activates innate immune cells to produce interferon-α (IFN-α) and other cytokines both in vitro and in vivo. This immune-based mechanism provides activity against a number of viruses. In addition, it is also used for a reagent for inflammation and immunity disorder models. (The product is for research purpose only.)
References
- Imiquimod applied topically: a novel immune response modifier and new class of drug
- Imiquimod and resiquimod as novel immunomodulators
- Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential
- Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
- The antiviral activity of toll-like receptor 7 and 7/8 agonists
- Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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