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CAS RN: 26833-87-4 | Product Number: H1775
Homoharringtonine
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Purity: >98.0%(HPLC)
Synonyms:
- Cephalotaxine 4-Methyl (2R)-2-Hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
- O3-[(2R)-2,6-Dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$114.00
|
Contact Us | Contact Us | 11 |
|
| 50MG |
$343.00
|
Contact Us | Contact Us | 19 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | H1775 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__9H__3__9NO__9 = 545.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 26833-87-4 |
| Reaxys Registry Number | 5687925 |
| PubChem Substance ID | 468592045 |
| MDL Number | MFCD05618221 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 144.0 to 148.0 °C |
| Specific rotation | -119 to -125deg (C=0.3, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 146 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | FK0260000 |
Transport Information:
| UN Number (DOT-AIR) | UN1544 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | II |
| HS Number | 2939.79.0000 |
Application
Homoharringtonine: A Cephalotaxine Alkaloid with Antiviral and Anticancer Activities
Homoharringtonine is a cephalotaxine alkaloid originally found in Cephalotaxus hainanensis L.1) Homoharringtonine exhibits antiviral and anticancer activities, and immobilized ribosomes immediately after initiation of translation in eukaryotic systems. It has been reported that homoharringtonine induces apoptosis in human promyelocytic leukemic HL-60 cells.2,3) Therefore, homoharringtonine has been used for the treatment of chronic myeloid leukemia (CML). (The product is for research purpose only.)
References
- 1) Structures of harringtonine, isoharringtonine, and homoharringtonine
- 2) Homoharringtonine: history, current research, and future direction (a review)
- 3) Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009 (a review)
- 4) From traditional Chinese medicine to traditional cancer therapy (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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