Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 21187-98-4 | Product Number: G0381
Gliclazide
×
![]()
×
Purity: >98.5%(T)(HPLC)
Synonyms:
- 1-[3-Azabicyclo[3.3.0]oct-3-yl]-3-p-toluenesulfonylurea
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$66.00
|
2 | 1 | 17 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | G0381 |
| Purity / Analysis Method | >98.5%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__1N__3O__3S = 323.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 21187-98-4 |
| Reaxys Registry Number | 1657836 |
| PubChem Substance ID | 135726993 |
| Merck Index (14) | 4439 |
| MDL Number | MFCD00409893 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.5 area% |
| Purity(Neutralization titration) | min. 98.5 % |
| Melting point | 165.0 to 169.0 °C |
Properties (reference)
| Melting Point | 167 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Ethanol, Methanol |
GHS
Related Laws:
| RTECS# | YT4500000 |
Transport Information:
| HS Number | 2935.90.9500 |
Application
Gliclazide: A Sulfonylurea ATP-Dependent K+ Channel Antagonist
Gliclazide belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. Gliclazide also has hemovascular properties, such as the anti-oxidant, platelet inhibiting and fibrinolytic actions. In addition, gliclazide is characterized by poor solubility in water. Therefore, it has been studied to improve the solubility and bioavailability of drug. (The product is for research purpose only.)
References
- Gliclazide. An update of its pharmacological properties and therapeutic efficacy in non-insulin-dependent diabetes mellitus (a review)
- Sulfonylurea stimulation of insulin secretion (a review)
- Gliclazide modified release (a review)
- Improvement of water solubility and in vitro dissolution rate of gliclazide by complexation with β-cyclodextrin
- Enhancement of dissolution rate of gliclazide using solid dispersions with polyethylene glycol 6000
- Cogrinding as an approach to enhance dissolution rate of a poorly water-soluble drug (gliclazide)
- The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide, or glimperide in plasma
Application
Study of Sulfonylureas Receptors
References
- The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated potassium channel in insulin-secreting cells
- H. Schmid-Antomarchi, L. De Weille, M. Fosset, M. Lazdunski, J. Biol. Chem. 1987, 262, 15840.
- Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent potassium channels
- M. Fosset, J. R. De Weille, R. D. Green, H. Schmid-Antomarchi, M. Lazdunski, J. Biol. Chem. 1988, 263, 7933.
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.