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CAS RN: 209783-80-2 | Product Number: E1454
Entinostat
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Purity: >97.0%(HPLC)
Synonyms:
- Pyridin-3-ylmethyl [4-[(2-Aminophenyl)carbamoyl]benzyl]carbamate
- MS-275
- SNDX-275
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$130.00
|
Contact Us | Contact Us | 14 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | E1454 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__0N__4O__3 = 376.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 209783-80-2 |
| Reaxys Registry Number | 8442710 |
| PubChem Substance ID | 468591795 |
| MDL Number | MFCD08272435 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Melting point | 157.0 to 161.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 160 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | EY8572500 |
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2933.39.6191 |
Application
Entinostat: A Potent Histone Deacetylase (HDAC) Inhibitor
Entinostat (MS-275) is a potent histone deacetylase (HDAC) inhibitor which enhances histone acetylation by inhibiting the deacetylation reaction by HDAC, and promotes the expression of a gene group that acts to suppress various carcinogenesis shows an antitumor effect.1-5) In addition, it has been reported that entinostat preferentially inhibits HDAC1 compared with HDAC3 and has little or no effect against HDAC6 and HDAC8.5) (The product is for research purpose only.)
References
- 1) A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors
- 2) The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1
- 3) MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors
- 4) MS-275, a potent orally available inhibitor of histone deacetylases-The development of an anticancer agent (a review)
- 5) Histone Deacetylase Inhibitors: Overview and Perspectives (a review)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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