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CAS RN: 2140-67-2 | Product Number: D6076
N,N-Dimethylguanosine
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Purity: >95.0%(HPLC)
Synonyms:
- 2-Dimethylamino-6-oxypurine Riboside
- 2-(Dimethylamino)guanosine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25MG |
$173.00
|
Contact Us | 1 | 13 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D6076 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__7N__5O__5 = 311.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 2140-67-2 |
| Reaxys Registry Number | 47545 |
| MDL Number | MFCD00057049 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Water | max. 1.0 % |
| Specific rotation | -33.0 to -37.0 deg(C=0.1, 1M NaOHaq.) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 239 °C(dec.) |
GHS
Related Laws:
Transport Information:
| HS Number | 2934.99.9001 |
Application
N,N-Dimethylguanosine: a modified ribonucleoside in tRNA and rRNA
N,N-Dimethylguanosine (N2,N2-dimethylguanosine, m22G) is a modified ribonucleoside that has long been known to present in tRNA and rRNA. Recent studies have discovered that N,N-dimethylguanosine is a prevalent RNA modification in eukaryotes and has roles in cell viability and development through these effects to RNA as follows; RNA stability and RNA structure.1-3) In addition, there are reports that the levels of modified nucleosides, including N,N-dimethylguanosine, have served as potential biomarkers for cancer and various diseases in many studies.4,5)
References
- Enzymic formation of N2,N2-dimethylguanosine in eukaryotic tRNA: importance of the tRNA architecture (a review)
- Location of N2,N2-dimethylguanosine-specific tRNA methyltransferase
- Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m22G: A pairs
- Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension
- A Fast Capillary Electrophoresis Method for Separation and Quantification of Modified Nucleosides in Urinary Samples
Articles/Brochures
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Specifications
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