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CAS RN: 201530-41-8 | Product Number: D5905
Deferasirox
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Purity: >98.0%(HPLC)
Synonyms:
- 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic Acid
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 250MG |
$106.00
|
Contact Us | Contact Us | 31 |
|
| 1G |
$264.00
|
Contact Us | Contact Us | 23 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | D5905 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__1__5N__3O__4 = 373.37 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 201530-41-8 |
| Reaxys Registry Number | 8442898 |
| PubChem Substance ID | 468591634 |
| MDL Number | MFCD09951804 |
Specifications
| Appearance | White to Gray to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 262 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 0.02 mg/l 25 °C |
| Solubility (slightly sol. in) | Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | DG4438400 |
Transport Information:
| HS Number | 2933.99.7500 |
Application
Mitophagy research
Reference
- Iron loss triggers mitophagy through induction of mitochondrial ferritin
Application
Deferasirox: A Potent Chelating Agent with a Selective Affinity for Ferric Ion [Fe (III)]
Deferasirox (ICL670A) is a potent chelating agent with a selective affinity for ferric ion [Fe (III)]. Deferasirox binds with ferric ions to form neutral 2:1 (deferasirox:iron) complexes. And then, deferasirox has a lower binding affinity for other metals such as copper, aluminum and zinc than for iron. Deferasirox, an iron selective chelator, is used therapeutically in conditions of transfusional iron overload for the excretion of iron. (The product is for research purpose only.)
References
- ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
- ICL670A: preclinical profile (a review)
- Deferasirox: a review of its use in the management of transfusional chronic iron overload
- Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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