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CAS RN: 22494-42-4 | Product Number: D5875
Diflunisal
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Purity: >98.0%(GC)
Synonyms:
- 2',4'-Difluoro-4-hydroxybiphenyl-3-carboxylic Acid
- 2',4'-Difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$36.00
|
Contact Us | 1 | 3 |
|
| 25G |
$141.00
|
Contact Us | Contact Us | 19 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D5875 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__3H__8F__2O__3 = 250.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 22494-42-4 |
| Reaxys Registry Number | 2654431 |
| PubChem Substance ID | 468591619 |
| Merck Index (14) | 3146 |
| MDL Number | MFCD00057834 |
Specifications
| Appearance | White to Almost white powder to crystaline |
| Purity(GC) | min. 98.0 % |
| Melting point | 211.0 to 215.0 °C |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 215 °C |
| Maximum Absorption Wavelength | 253(H2O) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | DV2030000 |
Transport Information:
| HS Number | 2918.29.7500 |
Application
Diflunisal: A Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibits both COX-1 and COX-2.1) In addition, diflunisal has been reported to stabilize transthyretin (TTR) tetramers and prevents amyloid fibril formation in vitro, and diflunisal is expected to use for the treatment of amyloidosis.2,3) (The product is for research purpose only.)
References
- 1) Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis
- 2) Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis
- 3) Diflunisal for ATTR cardiac amyloidosis
- 4) Diflunisal (a review of the chemical and physical properties, synthesis, stability, methods of analysis, and pharmacology)
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Analytical Charts
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