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CAS RN: 866405-64-3 | Product Number: D5394
Dorsomorphin
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Purity: >97.0%(HPLC)
Synonyms:
- 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$211.00
|
1 | 1 | 14 |
|
| 50MG |
$634.00
|
1 | Contact Us | 29 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | D5394 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__5N__5O = 399.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 866405-64-3 |
| Reaxys Registry Number | 11725482 |
| PubChem Substance ID | 354335063 |
| MDL Number | MFCD08705402 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
Properties (reference)
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| HS Number | 2933.59.8000 |
Application
Research on regenerative medicine
Dorsomorphin promotes self-renewal of human embryonic stem cells (hESCs) and supports stem cell self-renewal over the long term (five or more passes).1)
Reference
- 1) Dorsomorphin promotes human embryonic stem cell self-renewal
Application
Dorsomorphin: A Selective Inhibitor of Bone Morphogenetic Protein (BMP) Signaling
Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. BMPs are multi-functional growth factors that belong to the transforming growth factor β (TGF-β) superfamily. Therefore, it is considered that BMP signals have essential physiological roles in mature organisms. Recent studies on dorsomorphin as a BMP inhibitor show its application of in the field such as osteogenesis, developmental patterning and iron homeostasis.
References
- Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
- Small-molecule dissection of BMP signaling (a review)
- Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
- Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells
PubMed Literature
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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