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CAS RN: 761440-16-8 | Product Number: D5068
2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine
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![2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine")
Purity: >97.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 200MG |
$81.00
|
1 | 1 | 27 |
|
| 1G |
$240.00
|
2 | Contact Us | 10 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | D5068 |
| Purity / Analysis Method | >97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__3H__1__3Cl__2N__3O__2S = 346.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 761440-16-8 |
| Reaxys Registry Number | 12052746 |
| PubChem Substance ID | 354333960 |
| MDL Number | MFCD12827956 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 149.0 to 153.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 151 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.59.8000 |
Application
A Synthetic Intermediate of Anaplastic Lymphoma Kinase (ALK) Inhibitors
This compound is used as a synthetic intermediate of anaplastic lymphoma kinase (ALK) inhibitors which have been reported their potential antitumor activities.
References
- Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
- Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities
- Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor
- Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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