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CAS RN: 35202-54-1 | Product Number: D4485
4,5-Dimethoxy-1-benzocyclobutenecarbonitrile
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 1-Cyano-4,5-dimethoxybenzocyclobutene
- 3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 1G |
$125.00
|
Contact Us | 1 | 4 |
|
| 5G |
$441.00
|
Contact Us | Contact Us | 9 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | D4485 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__1H__1__1NO__2 = 189.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 35202-54-1 |
| Reaxys Registry Number | 2213391 |
| PubChem Substance ID | 253661877 |
| MDL Number | MFCD01846132 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 84.0 to 88.0 °C |
Properties (reference)
| Melting Point | 86 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water.Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. |
Related Laws:
Transport Information:
| HS Number | 2926.90.4801 |
Application
A Synthetic Intermediate of Ivabradine Hydrochloride
This product has been used as a synthetic intermediate of ivabradine hydrochloride [I0847], which is a selective If current inhibitor.
References
- New synthetic route to (1S)-4,5-dimethoxy-1-[(methylamino)methyl]benzocyclobutane, a key intermediate of ivabradine
- Preparation of N-[[(benzocyclobutylalkyl)amino]alkyl]tetrahydro-3-benzazepin-2-ones and analogs as cardiovascular agents
- J. L. Peglion, J. Vian, J. P. Vilaine, N. Villeneuve, P. Janiak, J. P. Bidouard, EP534859 A1.
- Process for preparation of ivabradine via resolution of N-[[3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine
- P. Bose, U. B. R. Siripalli, A. S. Kandadai, WO2010072409 A1.
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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