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CAS RN: 53-85-0 | Product Number: D4292
5,6-Dichlorobenzimidazole 1-β-D-Ribofuranoside
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 5,6-Dichlorobenzimidazole Riboside
- 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole
- DRB
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$168.00
|
2 | 1 | 32 |
|
| 1G |
$988.00
|
1 | 1 | 19 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | D4292 |
| Purity / Analysis Method | >98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__2H__1__2Cl__2N__2O__4 = 319.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 53-85-0 |
| Reaxys Registry Number | 39123 |
| PubChem Substance ID | 253660379 |
| MDL Number | MFCD00036785 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 220.0 to 224.0 °C |
| Specific rotation [a]20/D | -66.0 ～ -68.0 deg(C=2, Pyridine) |
Properties (reference)
| Melting Point | 222 °C |
| Specific Rotation | -67° (C=2,Pyridine) |
| Maximum Absorption Wavelength | 296 nm |
GHS
Related Laws:
| RTECS# | DD7310000 |
Transport Information:
| HS Number | 2934.99.4400 |
Application
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB): A Selective Inhibitor of Transcription Elongation by RNA Polymerase II
5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DRB) is a selective inhibitor of transcription elongation by RNA polymerase II, and then it inhibits of mRNA synthesis in eukaryotic cells. The inhibition can trigger p53-dependent apotosis of tumor cells. DRB can also inhibit HIV transcription by targeting elongation enhanced by the HIV-encoded transactivator (Tat).
References
- 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro
- The transcriptional elongation inhibitor 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase
- Inhibition of RNA polymerase II as a trigger for the p53 response
- DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation
- Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB
PubMed Literature
Articles/Brochures
TCIMAIL
[TCIMAIL No.164] DRB : A Selective Inhibitor of Transcription Elongation by RNA Polymerase IIProduct Documents (Note: Some products will not have analytical charts available.)
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