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CAS RN: 2127-03-9 | Product Number: D1114
2,2'-Dipyridyl Disulfide [for Peptide Synthesis]
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![2,2'-Dipyridyl Disulfide [for Peptide Synthesis]](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "2,2'-Dipyridyl Disulfide [for Peptide Synthesis]")
Purity: >98.0%(GC)(T)
Synonyms:
- 2,2'-Dithiodipyridine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$54.00
|
10 | 2 | ≥100 |
|
| 25G |
$162.00
|
3 | 8 | ≥100 |
|
| 250G |
$801.00
|
21 | 9 | ≥60 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | D1114 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__0H__8N__2S__2 = 220.31 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 2127-03-9 |
| Reaxys Registry Number | 154629 |
| PubChem Substance ID | 87567675 |
| SDBS (AIST Spectral DB) | 12066 |
| MDL Number | MFCD00006287 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 57.0 to 60.0 °C |
| Solubility in Methanol | almost transparency |
Properties (reference)
| Melting Point | 58 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol, Acetone, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2933.39.9200 |
Application
TCI Practical Example: β-Lactamization through Condensation Reaction
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Used Chemicals
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Procedure
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To a solution of 3-amino-3-phenylpropionic acid (463 mg, 2.80 mmol) and triphenylphosphine (881 mg, 3.36 mmol) in acetonitrile (28 mL) was added 2,2'-dipyridyl disulfide (740 mg, 3.36 mmol) and the mixture was stirred at reflux for 3 hours. The solvent was removed under reduced pressure and the residue was purified by column chromatography (1:1 diethyl ether / dichloromethane on SiO2), giving white solid (250 mg, 56%).
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Experimenter’s Comments
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- (1) The reaction mixture was monitored by TLC (Et2O / CH2Cl2 = 1 : 1, Rf = 0.35).
- (2) This condition is also utilized in the Corey-Nicolaou macrolactonization.
- Synthesis of novel macrocyclic lactones in the prostaglandin and polyether antibiotic series
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Analytical Data（4-Phenyl-2-azetidinone）
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1H NMR (400 MHz, CDCl3); δ 7.27 – 7.38 (m, 5H), 6.47 (br s, 1H), 4.70 (dd, 1H, J = 2.4, 5.2 Hz), 3.41 (ddd, 1H, J = 2.4, 5.2, 14.8 Hz), 2.84 (dd, 1H, J = 2.0, 14.8 Hz).
13C NMR (101 MHz, CDCl3); δ 168.2, 140.1, 128.8, 128.2, 125.6, 50.3, 47.9.
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Lead Reference
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- Ph3P-(PyS)2-CH3CN as an excellent condensing system for β-lactam formation from β-amino acids
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Other References
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- Synthesis of (S)- and (R)-4[(methoxycarbonyl)methyl]-2-azetidinone by chemicoenzymic approach
PubMed Literature
Articles/Brochures
TCIMAIL
[Product Highlights] Chiral Derivatization Reagent Possessing a Pyridylthiourea Structure[TCI Practical Example] β-Lactamization through Condensation Reaction
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
C of A & Other Certificates
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Analytical Charts
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