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CAS RN: 29671-92-9 | Product Number: C3199
Chloroformamidine Hydrochloride
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Purity: >98.0%(T)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$36.00
|
3 | 1 | 9 |
|
| 25G |
$106.00
|
1 | 1 | ≥60 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | C3199 |
| Purity / Analysis Method | >98.0%(T)(N) |
| Molecular Formula / Molecular Weight | CH__3ClN__2·HCl = 114.96 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 29671-92-9 |
| Reaxys Registry Number | 3551122 |
| PubChem Substance ID | 354333142 |
| MDL Number | MFCD00035527 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Purity(Argentometric Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 180 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2925.29.9000 |
Application
An Amidine Salt Useful for Construction of 2-Aminopyrimidines
Synthesis of thieno[2,3-d]pyrimidin-4(3H)-one derivative 21)
A mixture of 1 (0.3 g, 1.13 mmol), chloroformamidine hydrochloride (0.33 g, 2.83 mmol), and dimethylsulfone (0.53 g, 5.65 mmol) is heated at 130 °C for 30 min. After the mixture is cooled to room temperature, water (10 mL) is added and ammonium hydroxide is used to neutralize the suspension. The solid is filtered off, washed with water, and dried. The crude residue is purified by flash chromatography on silica gel (CH2Cl2 /MeOH 10:1) to yield 2 as a white solid (0.28 g, 95%).
A mixture of 1 (0.3 g, 1.13 mmol), chloroformamidine hydrochloride (0.33 g, 2.83 mmol), and dimethylsulfone (0.53 g, 5.65 mmol) is heated at 130 °C for 30 min. After the mixture is cooled to room temperature, water (10 mL) is added and ammonium hydroxide is used to neutralize the suspension. The solid is filtered off, washed with water, and dried. The crude residue is purified by flash chromatography on silica gel (CH2Cl2 /MeOH 10:1) to yield 2 as a white solid (0.28 g, 95%).
References
- 1)Discovery of 7-N-Piperazinylthiazolo[5,4-d]pyrimidine Analogues as a Novel Class of Immunosuppressive Agents with in Vivo Biological Activity
- 2)Targeting the α-folate receptor with cyclopenta[g]quinazoline-based inhibitors of thymidylate synthase
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