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CAS RN: 7205-91-6 | Product Number: C0912
α-Chlorothioanisole
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Purity: >95.0%(GC)
Synonyms:
- Chloromethyl Phenyl Sulfide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$54.00
|
Contact Us | Contact Us | ≥40 |
|
| 25G |
$158.00
|
Contact Us | 1 | 20 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | C0912 |
| Purity / Analysis Method | >95.0%(GC) |
| Molecular Formula / Molecular Weight | C__7H__7ClS = 158.64 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 7205-91-6 |
| Reaxys Registry Number | 1617369 |
| PubChem Substance ID | 87565965 |
| SDBS (AIST Spectral DB) | 5670 |
| MDL Number | MFCD00000921 |
Specifications
| Appearance | Colorless to Light yellow clear liquid |
| Purity(GC) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Flash point | 101 °C |
| Specific Gravity (20/20) | 1.23 |
| Refractive Index | 1.60 |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| UN Number (DOT-AIR) | UN3532 |
| Class (DOT-AIR) | 4.1 |
| Packing Group (TCI-A) | III |
| HS Number | 2930.90.2900 |
Application
Protection of Phenols
Typical Procedure:
[Protection of p-bromophenol]
To a solution of p-bromophenol (0.692 g, 4.00 mmol) in dry HMPA (distilled from CaH2) (20 mL) under N2 is added sodium hydride (0.106 g, 4.40 mmol). After stirring at room temperature for 0.5 h, chloromethyl phenyl sulfide (0.636 g, 4.00 mmol) and sodium iodide (0.600 g, 4.00 mmol) are added and stirring at room temperature is continued for 18 h. The mixture is partitioned between benzene and water; drying and evaporation of benzene extracts gives an oil which is purified by Kugelrohr distillation to provide pure product (1.03 g, Y. 87%).
[Deprotection]
To a solution of p-bromophenyl phenylthiomethyl ether (0.295 g, 1.00 mmol) in CH3CN―H2O (4:1, 10 mL) is added mercuric chloride (0.407 g, 1.50 mmol). The resulting suspension is refluxed for 42 h, diluted with ethyl ether, and filtered through celite. Aqueous extraction followed by drying and solvent evaporation gives spectrally and chromatographically pure p-bromophenol (0.155 g, Y. 90%).
[Protection of p-bromophenol]
To a solution of p-bromophenol (0.692 g, 4.00 mmol) in dry HMPA (distilled from CaH2) (20 mL) under N2 is added sodium hydride (0.106 g, 4.40 mmol). After stirring at room temperature for 0.5 h, chloromethyl phenyl sulfide (0.636 g, 4.00 mmol) and sodium iodide (0.600 g, 4.00 mmol) are added and stirring at room temperature is continued for 18 h. The mixture is partitioned between benzene and water; drying and evaporation of benzene extracts gives an oil which is purified by Kugelrohr distillation to provide pure product (1.03 g, Y. 87%).
[Deprotection]
To a solution of p-bromophenyl phenylthiomethyl ether (0.295 g, 1.00 mmol) in CH3CN―H2O (4:1, 10 mL) is added mercuric chloride (0.407 g, 1.50 mmol). The resulting suspension is refluxed for 42 h, diluted with ethyl ether, and filtered through celite. Aqueous extraction followed by drying and solvent evaporation gives spectrally and chromatographically pure p-bromophenol (0.155 g, Y. 90%).
References
- A new protecting group for phenols: phenylthiomethyl (PTM) ethers
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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