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CAS RN: | Product Number: B6160
BGP-15 Hydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- N-[2-Hydroxy-3-(piperidin-1-yl)propoxy]nicotinimidamide Hydrochloride
- N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide Hydrochloride
- NP-51 Hydrochloride
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5MG |
$105.00
|
Contact Us | Contact Us | 26 |
|
| 25MG |
$368.00
|
Contact Us | Contact Us | 32 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | B6160 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__2__2N__4O__2·xHCl |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Related CAS RN | 459809-32-6&66611-37-8 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 200.0 to 204.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 202 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.39.9200 |
Application
BGP-15: A PARP Inhibitor and an Insulin Sensitizer
Poly (ADP-ribose) polymerases (PARPs) is a family of enzymes involved in a number of cellular processes such as DNA repair, genomic stability, and apoptosis.1) BGP-15 has been used in cancer research because of its PARP inhibition.2) In addition, BGP-15 has recently reported as a pharmacological inducer of heat shock protein 72 (HSP72) and a new insulin sensitizer agent candidate.3,4) (The product is for research purpose only.)
References
- 1) Role of PARP Inhibitors in Cancer Biology and Therapy
- 2) Effect of Poly(ADP-Ribose) Polymerase Inhibitors on the Ischemia-Reperfusion-Induced Oxidative Cell Damage and Mitochondrial Metabolism in Langendorff Heart Perfusion System
- 3) HSP72 protects against obesity-induced insulin resistance
- 4) Pharmacological overview of the BGP-15 chemical agent as a new drug candidate for the treatment of symptoms of metabolic syndrome
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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