Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 6398-98-7 | Product Number: A3133
Amodiaquine Dihydrochloride Dihydrate
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-[(7-Chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol Dihydrochloride Dihydrate
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 5G |
$28.00
|
Contact Us | 1 | ≥80 |
|
| 25G |
$88.00
|
3 | 1 | 36 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3133 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__2ClN__3O·2HCl·2H__2O = 464.81 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 6398-98-7 |
| Related CAS RN | 86-42-0&69-44-3 |
| Reaxys Registry Number | 17163077 |
| PubChem Substance ID | 354335166 |
| Merck Index (14) | 572 |
| MDL Number | MFCD00078857 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Water | 7.0 to 9.0 % |
Properties (reference)
| Maximum Absorption Wavelength | 342 nm (MeOH) |
| Solubility in water | Soluble |
| Solubility (soluble in) | Methanol |
| Solubility (insoluble in) | Alcohol |
GHS
Related Laws:
Transport Information:
| HS Number | 2933.49.7000 |
Application
Amodiaquine Dihydrochloride: A 4-Aminoquinoline Antimalarial Agent
Amodiaquine dihydrochloride is a synthetic 4-aminoquinoline antimalarial agent. Amodiaquine is mainly metabolized hepatically towards its major active metabolite N-desethylamodiaquine, by the cytochrome P450 2C8 (CYP2C8). The mechanism of action of amodiaquine against plasmodium is not yet completely understood, but the most plausible explanation is that the active metabolite penetrate the infected red blood cells and prevent the parasite from polymerizing heme into a malarial metabolite called hemozoin, leading to parasite death. Recently, the antimalarial combination of amodiaquine plus artesunate [A2191] has been extensively studied and good efficacy and tolerability has been reported. (The product is for research purpose only.)
References
- Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate (a review)
- CYP2C8 and antimalaria drug efficacy (a review)
- Artemisinin-based combination treatment of falciparum malaria
- Amodiaquine hydrochloride (a review on the synthesis, properties, analysis and pharmacology)
- High-performance liquid chromatographic method for determination of amodiaquine, chloroquine and their monodesethyl metabolites in biological samples
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.