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CAS RN: 41294-56-8 | Product Number: A3125
Alfacalcidol
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Purity: >95.0%(HPLC)
Synonyms:
- 1α-Hydroxyvitamin D3
- 1α-Hydroxycholecalciferol
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 10MG |
$105.00
|
1 | 1 | 1 |
|
| 50MG |
$374.00
|
6 | Contact Us | ≥40 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3125 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__4__4O__2 = 400.65 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 41294-56-8 |
| Reaxys Registry Number | 2064794 |
| PubChem Substance ID | 354335206 |
| Merck Index (14) | 4819 |
| MDL Number | MFCD00868328 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 136.0 to 140.0 °C |
| Specific rotation [a]20/D | +34.0 to +38.0 deg(C=0.3, CHCL3) |
Properties (reference)
| Melting Point | 136 °C |
| Specific Rotation | 36° (C=0.3,CHCl3) |
| Maximum Absorption Wavelength | 264(Diethyl ether) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P270 : Do not eat, drink or smoke when using this product. P262 : Do not get in eyes, on skin, or on clothing. P271 : Use only outdoors or in a well-ventilated area. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing. P284 : Wear respiratory protection. P362 : Take off contaminated clothing and wash before reuse. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P350 + P310 : IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/ physician. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number (DOT-AIR) | UN2811 |
| Class (DOT-AIR) | 6.1 |
| Packing Group (TCI-A) | II |
| HS Number | 2936.29.5020 |
Application
Alfacalcidol: A Prodrug of Calcitriol, the Active Form of Vitamin D3
Alfacalcidol (1α-hydroxyvitamin D3) is a prodrug of calcitriol (1α,25-dihydroxyvitamin D3) [C3078] which is the active form of vitamin D3 (cholecalciferol) [
C0314]. The natural supply of vitamin D3 in human being mainly depends on ultraviolet light for conversion of 7-dehydrocholesterol [CAS: 434-16-2] to vitamin D3 in the skin. The transformation (hydroxylation at position 25) of vitamin D3 is catalyzed by enzymes in the liver and the kidney to produce calcitriol. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract.
However, alfacalcidol is rapidly hydroxylated to calcitriol in the liver, effectively bypassing the critical renal metabolic conversion. Therefore, alfacalcidol is effective for patients with chronic renal failure to remedy vitamin D3 deficiency, and to increase the bone resorption and the bone formation. (The product is for research purpose only.)
C0314]. The natural supply of vitamin D3 in human being mainly depends on ultraviolet light for conversion of 7-dehydrocholesterol [CAS: 434-16-2] to vitamin D3 in the skin. The transformation (hydroxylation at position 25) of vitamin D3 is catalyzed by enzymes in the liver and the kidney to produce calcitriol. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract.
However, alfacalcidol is rapidly hydroxylated to calcitriol in the liver, effectively bypassing the critical renal metabolic conversion. Therefore, alfacalcidol is effective for patients with chronic renal failure to remedy vitamin D3 deficiency, and to increase the bone resorption and the bone formation. (The product is for research purpose only.)
References
- Metabolism of 1α-hydroxyvitamin D3 to 1α,25-dihydroxyvitamin D3 in perfused rat liver
- Rate of reversal of hypercalcaemia and hypercalciuria induced by vitamin D and its 1alpha-hydroxylated derivatives.
- Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen
- A new look at the most successful prodrugs for active vitamin D (D hormone): alfacalcidol and doxercalciferol (a review)
- Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3
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