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CAS RN: 2627-69-2 | Product Number: A2528
5-Aminoimidazole-4-carboxamide 1-β-D-Ribofuranoside
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Purity: >98.0%(HPLC)
Synonyms:
- 5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide
- Acadesine
- AICAR
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$97.00
|
Contact Us | Contact Us | 7 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | A2528 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__4N__4O__5 = 258.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 2627-69-2 |
| Reaxys Registry Number | 38255 |
| PubChem Substance ID | 253659575 |
| Merck Index (14) | 16 |
| MDL Number | MFCD00869751 |
Specifications
| Appearance | White to Light yellow to Light red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -61.0 to -66.0 deg(C=1、H2O) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 212 °C |
| Specific Rotation | -63° (C=1,H2O) |
| Maximum Absorption Wavelength | 265(NaOH) nm |
GHS
| Pictogram |
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| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
Transport Information:
| HS Number | 2933.29.9000 |
Application
Autophagy research
References
- AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
- Inhibition of Hepatocytic Autophagy by Adenosine, Aminoimidazole-4-carboxamide Riboside, and N6-Mercaptopurine Riboside. EVIDENCE FOR INVOLVEMENT OF AMP-ACTIVATED PROTEIN KINASE
Application
Acadesine (AICAR): AMP-Activated Protein Kinase Activator
5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (Acadesine or AICAR) has been extensively used in vitro and in vivo to activate AMP-activated protein kinase (AMPK). AMPK stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy consuming functions, such as protein and cholesterol synthesis. Therefore, acadesine may have applications in treating disorders such as type 2 diabetes and Alzheimer's disease. Recently, it has been shown that acadesine induces leukemia apoptosis. (The product is for research purpose only.)
References
- 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
- J. M. Corton, J. G. Gillespie, S. A. Hawley, D. G. Hardie, Eur. J. Biochem. 1995, 229, 558.
- AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
- G. F. Merrill, E. J. Kurth, D. G. Hardie, W. W. Winder, Am. J. Physiol. 1997, 273, E1107.
- Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
- T. Hayashi, M. F. Hirshman, E. J. Kurth, W. W. Winder, L. J. Goodyear, Diabetes 1998, 47, 1369.
- Knockout of the α2 but Not α1 5'-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside- but Not Contraction-induced Glucose Uptake in Skeletal Muscle
- 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside Inhibits Cancer Cell Proliferation in Vitro and in Vivo via AMP-activated Protein Kinase
- AMP-activated protein kinase and muscle glucose uptake (a review)
- AMP-activated protein kinase: a potential player in Alzheimer's disease (a review)
PubMed Literature
Articles/Brochures
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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