Make sure to sign up for an account today for exclusive coupons and free shipping on orders over $75!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 1937-19-5 | Product Number: A1129
Aminoguanidine Hydrochloride
×
![]()
×
Purity: >98.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 25G |
$55.00
|
2 | 4 | ≥100 |
|
| 100G |
$119.00
|
10 | Contact Us | ≥60 |
|
| 500G |
$267.00
|
9 | 7 | 31 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
* To send your quote request for bulk quantities, please click on the "Request Quote" button. Please note that we cannot offer bulk quantities for some products.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A1129 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | CH__6N__4·HCl = 110.55 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 1937-19-5 |
| Related CAS RN | 79-17-4 |
| Reaxys Registry Number | 3909606 |
| PubChem Substance ID | 87562613 |
| MDL Number | MFCD00039074 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity( Potassium iodate Method) | min. 98.0 % |
| Melting point | 161.0 to 167.0 °C |
Properties (reference)
| Melting Point | 165 °C |
| Solubility (soluble in) | Alcohol |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. |
Related Laws:
| RTECS# | ME8430000 |
Transport Information:
| HS Number | 2925.29.9000 |
Application
Two Biological Effects of Aminoguanidine Hydrochloride
It is reported that aminoguanidine hydrochloride has two important biological effects. Firstly, it is effective for the prevention of formation of advanced glycation endproducts (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging.1-3) Aminoguanidine hydrochloride reacts rapidly with in vivo glycation α,β-dicarbonyl products such as methylglyoxal, glyoxal [G0152], and 3-deoxyglucosone to prevent the formation of AGEs.
Secondly, it inhibits of the individual isoforms of nitric oxide synthase (iNOS) which is one of three key enzymes generating nitric oxide (NO) from L-arginine [ A0526]. iNOS-derived nitric oxide plays an important role in numerous physiological (e.g. blood pressure regulation) and pathophysiological (e.g. inflammation) conditions. 3-6) (The product is for research purpose only.)
Secondly, it inhibits of the individual isoforms of nitric oxide synthase (iNOS) which is one of three key enzymes generating nitric oxide (NO) from L-arginine [ A0526]. iNOS-derived nitric oxide plays an important role in numerous physiological (e.g. blood pressure regulation) and pathophysiological (e.g. inflammation) conditions. 3-6) (The product is for research purpose only.)
References
- 1)Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking
- 2)Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts (a review)
- 3)Biological effects of aminoguanidine: An update (a review)
- 4)Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction
- 5)Selective inhibition of the inducible nitric oxide synthase by aminoguanidine
- 6)Selective inhibition of inducible nitric oxide synthase by aminoguanidine (a review)
PubMed Literature
Articles/Brochures
TCIMAIL
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.