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Published TCIMAIL newest issue No.197
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CAS RN: 93183-36-9 | Product Number: D6204
Diisopropylammonium Tetrazol-1-ide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Diisopropylammonium Tetrazolide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€100.00
|
1 | 32 |
|
| 25G |
€298.00
|
Contact Us | 8 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D6204 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__1__5N·CH__2N__4 = 171.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 93183-36-9 |
| Reaxys Registry Number | 3569216 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 150.0 to 154.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 152 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2933998090 |
Application
TCI Practical Example: Phosphoroamidite Synthesis Using Diisopropylammonium Tetrazole
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Used Chemicals
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Procedure
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2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite (0.7 mL, 2.2 mmol, 1.2 eq.) was added to a solution of DMT-T (1.0 g, 1.8 mmol) and diisopropylammonium tetrazole (160 mg, 0.92 mmol, 0.5 eq.) in dichloromethane (9.2 mL) at room temperature. After the completion of the reaction, saturated aq. NaHCO3 (5 mL) was added to the solution and extracted with dichloromethane (15 mL, twice). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (hexane:ethyl acetate = 70:30 - 50:50, 2% of triethylamine was added to the eluents) to give 1 (1.2 g, 88% yield) as a white crystal.
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Experimenter’s Comments
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The reaction solution was monitored by NMR.
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Analytical Data
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Compound 1
1H NMR (400 MHz, CDCl3); δ 11.36 (s, 1H), 7.50 (d, J = 4.0 Hz, 1H), 7.36-7.20 (m, 9H), 6.87-6.83 (m, 4H), 6.16-6.15 (m, 1H), 4.56-4.49 (m, 1H), 3.99 (d, J = 4.0 Hz, 1H), 3.73-3.72 (m, 1H), 3.22-3.19 (m, 1H), 2.72 (t, J = 8.0 Hz, 1H), 2.62 (t, J = 1.2 Hz, 1H), 2.41-2.31 (m, 1H), 1.44 (d, J = 1.2 Hz, 3H), 1.18-1.06 (m, 12H).
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Lead Reference
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- Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogs
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Other Reference
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- Microwave-assisted preparation of nucleoside-phosphoramidites
Product Documents (Note: Some products will not have analytical charts available.)
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