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Published TCIMAIL newest issue No.197
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CAS RN: 32986-56-4 | Product Number: T2503
Tobramycin
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Purity: >94.0%(T)
Synonyms:
- O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€109.00
|
4 | 6 |
|
| 25G |
€392.00
|
2 | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2503 |
| Purity / Analysis Method | >94.0%(T) |
| Molecular Formula / Molecular Weight | C__1__8H__3__7N__5O__9 = 467.52 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 32986-56-4 |
| Reaxys Registry Number | 1357507 |
| PubChem Substance ID | 87560061 |
| Merck Index (14) | 9490 |
| MDL Number | MFCD00077885 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(Nonaqueous Titration) | min. 94.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | +138.0 to +148.0 deg(C=4, H2O)(calcd.on anh.substance) |
| Water | max. 8.0 % |
Properties (reference)
| Melting Point | 178 °C |
| Specific Rotation | 143° (C=4,H2O) |
| Solubility in water | Soluble |
GHS
Related Laws:
| EC Number | 251-322-5 |
| RTECS# | WK2100000 |
Transport Information:
| HS Number | 2941900000 |
Application
RNA aptamer research
References
- Direct Selection of RNA Beacon Aptamers
- Specific binding of aminoglycoside antibiotics to RNA
Application
Tobramycin: An Aminoglycoside Antibiotic Active Against Pseudomonas Aeruginosa
Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius, and is similar in structure to gentamicin [G0383]. Tobramycin interacts with the 30s and 50s subunit of prokaryotic ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Tobramycin is more active than gentamicin against Pseudomonas aeruginosa and active against many gentamicin resistant strains. Recently, inhaled tobramycin is effective in treating chronic Pseudomonas aeruginosa lung infection in cystic fibrosis. (The product is for research purpose only.)
References
- Tobramycin: a review of its antibacterial and pharmacokinetic properties and therapeutic use
- The aminoglycosides: streptomycin, kanamycin, gentamicin, tobramycin, amikacin, netilmicin, and sisomicin (a review)
- Tobramycin Inhalation Powder: a novel drug delivery system for treating chronic Pseudomonas aeruginosa infection in cystic fibrosis
- Tobramycin Inhalation Powder: A Review of Its Use in the Treatment of Chronic Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis
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