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Published TCIMAIL newest issue No.197
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CAS RN: 21679-14-1 | Product Number: F0658
Fludarabine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 9-β-D-Arabinofuranosyl-2-fluoroadenine
- 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
- 2-Fluoroadenine Arabinosid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€35.00
|
1 | 21 |
|
| 1G |
€115.00
|
1 | 11 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | F0658 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__2FN__5O__4 = 285.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| Packaging and Container | 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 21679-14-1 |
| Reaxys Registry Number | 1225932 |
| PubChem Substance ID | 468591803 |
| Merck Index (14) | 4126 |
| MDL Number | MFCD00132942 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +12.0 to +18.0 deg(C=0.1, ethanol) |
Properties (reference)
| Melting Point | 260 °C |
| Specific Rotation | 18° (C=0.1,EtOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 244-525-5 |
| RTECS# | AU6207000 |
Transport Information:
| HS Number | 2934999090 |
Application
Fludarabine (F-ara-A): An Antimetabolite Antineoplastic Nucleoside
Fludarabine (F-ara-A), an antimetabolite antineoplastic nucleoside, is a 2-fluorinated nucleoside analog of the antiviral agent vidarabine (ara-A) [V0098] that is relatively resistant to deamination by adenosine deaminase. F-ara-A is rapidly phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP (F-ara-ATP). The active metabolite acts by inhibiting DNA and RNA polymerases thus preventing DNA and RNA syntheses in proliferating cells. In clinical, its monophosphate, F-ara-AMP, is used for the treatment of chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin's lymphoma. (The product is for research purpose only.)
References
- Termination of DNA synthesis by 9-β-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity
- Fludarabine: pharmacokinetics, mechanisms of action, and rationales for combination therapies (a review)
- Cellular and clinical pharmacology of fludarabine (a review)
- Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity
- A highly sensitive high-performance liquid chromatography-mass spectrometry method for quantification of fludarabine triphosphate in leukemic cells
Product Documents (Note: Some products will not have analytical charts available.)
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