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CAS RN: 26116-56-3 | Product Number: E1555
Erythromycylamine
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Purity: >90.0%(qNMR)
Synonyms:
- (9S)-9-Amino-9-deoxoerythromycin
- 9(S)-Erythromycylamine
- (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-Amino-6-[[(2S,3R,4S)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
160,00 €
|
Contact Us | 3 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E1555 |
| Purity / Analysis Method | >90.0%(qNMR) |
| Molecular Formula / Molecular Weight | C__3__7H__7__0N__2O__1__2 = 734.97 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 26116-56-3 |
| Reaxys Registry Number | 4241492 |
| MDL Number | MFCD00872156 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(qNMR) | min. 90.0 % |
| Specific rotation | -45.0 to -49.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 129 °C |
| Degree of solubility in water | 1.22 g/l 20 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H318 : Causes serious eye damage. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P280 : Wear eye protection/ face protection. P391 : Collect spillage. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
| RTECS# | KF4590000 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
Application
Erythromycylamine: An Active Metabolite of a Macrolide Antibiotic Dirithromycin
Erythromycylamine is the major active metabolite of dirithromycin [D5495], derived from a macrolide antibiotic erythromycin [E0751].1) Erythromycylamine has excellent activity against Campylobacter, a type of bacteria that can cause diarrheal disease.2) (The product is for research purpose only.)
References
- 1) Synthesis and antimicrobial evaluation of dirithromycin (ASE 136; LY237216), a new macrolide antibiotic derived from erythromycin
- 2) Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides
- 3) Quantitative determination of erythromycylamine in human plasma by liquid chromatography-mass spectrometry and its application in a bioequivalence study of dirithromycin
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