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Published TCIMAIL newest issue No.197
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CAS RN: 67-97-0 | Product Number: C0314
Cholecalciferol
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Purity: >98.0%(HPLC)
Synonyms:
- 7-Dehydrocholesterol, activated
- Vitamin D3
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€32.00
|
21 | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C0314 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__7H__4__4O = 384.65 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 67-97-0 |
| PubChem Substance ID | 125308742 |
| SDBS (AIST Spectral DB) | 10003 |
| Merck Index (14) | 10019 |
| MDL Number | MFCD00078131 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | +103 to +112 deg(C=0.5, EtOH) |
| Absorbance | 0.450 to 0.510(10mg/L, EtOH, 263.0 to 267.0 nm) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 86 °C |
| Specific Rotation | 108° (C=0.5,EtOH) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Alcohol, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled. H360 : May damage fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P260 : Do not breathe dust. P262 : Do not get in eyes, on skin, or on clothing. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 200-673-2 |
| RTECS# | VS2900000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2936290000 |
Application
Efflux pump inhibitor
References
- Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps
Application
Cholecalciferol (Vitamin D3): A Compound for the Maintenance of Normal Skeleton Architecture and Mineral Homeostasis
Cholecalciferol (Vitamin D3) is known for the maintenance of normal skeleton architecture and mineral homeostasis. Vitamin D3 is synthesized from 7-dehydrocholesterol [CAS: 434-16-2] in the skin under the influence of UV light, or it is obtained from food, especially fatty fish. The transformation (hydroxylation) of vitamin D3 is catalyzed by enzymes in the liver and the kidney to produce calcitriol [C3078] (other name: 1α,25-dihydroxyvitamin D3), the active form of vitamin D3. Calcitriol is active in the regulation of the absorption of calcium from the gastrointestinal tract. (The product is for research purpose only.)
References
- Overview of general physiologic features and functions of vitamin D (a review)
- Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease (a review)
- Enzymes involved in the activation and inactivation of vitamin D (a review)
- Vitamin D physiology (a review)
- Analytical measurement and clinical relevance of vitamin D3 C3-epimer (a review)
- The role of vitamin D in reducing cancer risk and progression (a review)
PubMed Literature
Articles/Brochures
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