Modified HSA for Click Chemistry

HSA-DBCO (1) is a complex of human serum albumin (HSA) and dibenzocyclooctyne (DBCO) moiety, which is used as a linker for the copper-free click reaction. 1 easily reacts with azide compounds to form a conjugate by just mixing.^1,2) Generally, HSA can be coated on a variety of plates and material surfaces, so 1 can be used to prepare conjugated products for various types of experiments.

References

• 1) Bioorthogonal chemistry for ⁶⁸Ga radiolabelling of DOTA-containing compounds
• H. L. Evans , L. Carroll, E. O. Aboagye, A. C. Spivey, J. Label. Compd. Radiopharm. 2014, 57, 291.
• 2) From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions
• E. M. Sletten, C. R. Bertozzi, Acc. Chem. Res. 2011, 44, 666.

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