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Activin Receptor-like Kinase Inhibitor
No.186(Spring 2021)
1
SB431542 (1) is a specific and potent inhibitor of the activin receptor-like kinase (ALK) family, e.g., ALK4, ALK5, ALK7.1) 1 can also inhibit TGF-β-mediated activation of SMAD and induction of fibronectin and collagen expression in TGF-β-response cell lines.2)
Since Yamanaka et al. identified reprogramming factors for iPS (induced pluripotent stem) cells from somatic sells,3) chemical substitutes for these factors have also been developed.4,5) 1 can also replace Sox2, in reprogramming mouse fibroblasts to iPS cells.6)
The product is for research purposes only.
References
- 1) SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
- 2) Inhibition of transforming growth factor (TGF)-β1–induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542
- 3) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
- 4) Dissecting direct reprogramming through integrative genomic analysis
- 5) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
- 6) A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog
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