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Topoisomerase Inhibitor
No.177(April 2018)
Gatifloxacin (1) is one of the fluoroquinolone antibiotics and shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria.1) 1 inhibits bacterial DNA gyrase and topoisomerase IV (Table 1).2) Furthermore, 1 promotes short-term self-renewal and differentiation of human embryonic stem cells.3)
Table 1. Inhibition of type II topoisomerase by Gatifloxacin2)
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References
- 1)In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinoline
- 2)Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases
- 3)High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells
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