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Bone Resorption Inhibitor

Bisphosphonates (BPs) are very effective inhibitors of bone resorption in vivo and in vitro. Disodium clodronate tetrahydrate (1) is one of the BPs and is classified in the first-generation BPs.1,2)
BPs are known not only as a bone resorption inhibitor but also as an anti-tumor.3) Tumor associated macrophages (TAMs) play many roles in tumor progression; tumor cell growth, migration, invasion, metastasis, and angiogenesis, etc.3) Effects of BPs on TAMs, i.e., BP-induced macrophage depletion, have been reported in detail.3) In such studies, liposome-encapsulated clodronate has been applied for targeting of macrophages.4-7)

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